Updates & Changelog

AI moves fast, and this guide evolves with it. This page tracks major updates, new modules, and significant revisions. Check back periodically to see what's changed.

v1.5 — April 2026

Module Updates

• The Big Three — Added ChatGPT for Clinicians (free verified-clinician tier) and ChatGPT for Healthcare (enterprise BAA tier, deployed at UCSF, Cedars-Sinai, MSK, Stanford Children's, Boston Children's, HCA, Baylor Scott & White, AdventHealth) to the ChatGPT tier grid; clarified that the free clinician tier is not covered by a BAA. Updated reasoning-model references from o1/o3 to GPT-5.5 and GPT-5.5 Pro. Refreshed the HIPAA/BAA comparison table.
• PHI, HIPAA, and AI — Expanded the BAA Availability list to distinguish ChatGPT for Clinicians (no BAA) from ChatGPT for Healthcare (BAA available, encryption keys, audit logs, data residency).
• AI Image and Video Creation — Replaced the GPT Image 1.5 section with ChatGPT Images 2.0 (Apr 21, 2026): #1 on Image Arena within 12 hours of launch, available on all plans including Free. Added Claude Design (Anthropic Labs, Apr 2026) to the Prioritize This callout. Updated conversational-iteration tool reference from GPT-4o to GPT-5.5.
• Running AI Models on Your Own Computer — Added Llama 4 Scout / Maverick (10M-token context, MoE architecture) to the Notable Models grid. Added a Muse Spark / open-vs-proprietary note to "Why Local Models Matter." Refreshed the Apple Silicon hardware table to include M4 / M4 Pro / M4 Max. Updated the example ollama pull command to a Llama 4 tag. Added DeepSeek V4 Pro to the Maximum Capability row. Migrated the HuggingFace Open Medical-LLM Leaderboard link from the deprecated blog post to the current Spaces deployment.
• The Art of the Ask (Prompting) — Updated stale model references (GPT-4o → GPT-5.5, Claude 3.5+ → Opus 4.7, Gemini 1.5 → 3.1 Pro). Softened the "knowledge cutoffs" limitation to acknowledge that modern frontends layer live web search on top of the frozen weights.
• How LLMs Think Like Clinicians — Fixed a broken 3Blue1Brown link (wrong URL format → 3blue1brown.com/lessons/mlp/). Added nuance to the "continuous learning" distinction now that ChatGPT, Claude, and Gemini layer persistent memory and live search on top of frozen weights. Updated context-window framing (128K → 200K–1M typical, with Llama 4 Scout up to 10M).
• Glossary — Updated the Reasoning Models entry (GPT-5.5, Claude Opus 4.7, Gemini 3.1 Pro Deep Think). Refreshed the Context Window examples for the April 2026 landscape. Updated the OpenAI, Google/DeepMind, and Meta company cards (added the Muse Spark proprietary/open split). Bumped FDA AI/ML device clearance count to 1,000+. Updated the page-footer timestamp from November 2025 to April 2026.

Headline events reflected

• OpenAI GPT-5.5 and GPT-5.5 Pro (Apr 23, 2026)
• OpenAI ChatGPT Images 2.0 (Apr 21, 2026)
• OpenAI ChatGPT for Clinicians and ChatGPT for Healthcare (rolling out 2026)
• Anthropic Claude Opus 4.7 with adaptive thinking (Apr 16, 2026)
• Anthropic Claude Design (Anthropic Labs, Apr 2026)
• DeepSeek V4 Flash and V4 Pro preview (Apr 24, 2026)
• Meta Muse Spark — first proprietary frontier model (Apr 8, 2026)

Operations

• Weekly audit routine updated with an empty-week failsafe: when a Sunday audit finds no pages overdue and no broken links, no GitHub issue is created. Issue creation is now the signal that work is pending.
• Enabled GitHub email notifications for the repo so audit issues land in the inbox automatically.

Site-Wide

• Bumped site version from v1.4 · 2026 to v1.5 · 2026 across all pages
• Updated card "Updated" dates on the homepage for the five revised modules (llm-thinking, prompting, image-video, local-models, glossary)

v1.4 — April 2026

Module Updates

• The Big Three — Claude Opus 4.7 (Apr 16, +13% coding, improved vision, same pricing as 4.6), GPT-5.4 and GPT-5.4-Cyber (Apr 14-16), GPT-Rosalind life-sciences model, Gemini 3 Flash as new default, Gemini Agent and Deep Think for Ultra. MedQA leaderboard snapshot (Apr 9): o4 Mini High 95.2%, Gemini 2.5 Pro 94.6%, Claude 3.7 Sonnet 92.3%.
• Clinical Decision Support — Abridge × NEJM + JAMA partnership (Apr 15) integrates peer-reviewed evidence into CDS grounded in patient conversations; NEJM AI publishes ChexGen (generative CXR foundation model); Bunkerhill Health FDA clearance for CAC/AVC on routine chest CT plus CMS OPPS billing pathway (Apr 1); Avo × EBSCO/DynaMed integration; FDA 2026 CDS guidance impact.
• Ambient AI Tools — JAMA multi-center study: 13.4 min EHR / 16.0 min documentation savings across 5 AMCs; Epic Art expanding to home care; 16M monthly Insights uses (3× since Nov 2025); 85% of Epic customers live with gen AI; Abridge named Fast Company Most Innovative 2026; Christ Hospital 69% early lung cancer detection via Epic AI incidental-finding extraction.
• When Patients Use AI Too — Hartford PatientGPT (K Health), Sutter + Reid piloting Epic's Emmie, Microsoft Copilot Health, OpenAI ChatGPT Health linking to patient portals. Microsoft 500k-conversation study: 40% of health queries on Copilot are about symptoms/conditions/treatments, 10.9% about interpreting symptoms or test results, 1-in-7 are proxy/caregiving, emotional-wellbeing queries spike at night. Ohio State: only 42% of Americans open to AI in care (down from 52% in 2024). Gallup: 25% use AI for health info, 4% strongly trust it.
• OpenClaw — Claude Code prompt-injection CVE after source-code leak (Adversa); GitHub Copilot CVE-2025-53773 (CVSS 9.6); Meta internal AI data leak (March); enterprise readiness still low (34.7% with dedicated defenses). Prompt injection remains OWASP LLM #1 in 2026.
• How AI Talks to Your Tools — MCP Dev Summit North America (NYC, ~1,200 attendees); MCP maintainer team expansion (Apr 8); early healthcare MCP proof-of-concepts at ISPOR 2026.
• PHI, HIPAA, and AI — HHS RFI on AI in clinical care (Apr 8); CareCloud EHR breach (Mar 16, 45,000+ providers affected); Netskope finding on healthcare workers uploading PHI to public GenAI; OCR enforcement pace.
• AI 101 for Medical Learners — AMA 2026 Physician Survey (1,692 physicians): AI use doubled to 81% since 2023; 76% say AI improves patient care; 70% see it as a burnout tool; 88% concerned about skill loss; 70% worry about trainees. NEJM “Educational Strategies for Clinical Supervision of AI Use.”
• Start Here — NotebookLM April updates: conversation auto-save, EPUB upload, create artifacts (Audio/Video Overview, slides, reports) from chat mid-conversation, Cinematic Video Overviews, Gemini Notebooks bidirectional sync.
• Vibe Coding — Cursor 3 Agents Window + Design Mode (Apr 2), Claude Code Design Review (Apr 17), OpenAI plugin inside Claude Code — the three tools are converging.

Site-Wide

• Moved 18 legacy cohort-era draft pages (week-*.html, *-orig.html, big-three-v1.0-archive.html) into archive/. No live page linked to them.
• Stood up a weekly scheduled remote agent (Sundays 12:00 CT) that audits the site against the prior week's AI news and files a GitHub issue with a punch list and draft updates entry.
• Bumped site version from v1.3 · 2026 to v1.4 · 2026 across all pages.

v1.3 — March 2026

New Content

• AI News — 18 new stories covering GPT-5.4, HIMSS 2026 agentic AI theme, Doctronic jailbreak, Perplexity Comet browser exploits, RecovryAI FDA Breakthrough, Claude Sonnet 4.6, Gemini 3.1 Pro, Meta Llama 4, athenahealth free ambient scribe, Nabla vs DAX RCT, DeepSeek V4 controversy, AI chatbots and mental illness, and more

Module Updates

• OpenClaw — Major refresh: ClawHavoc supply chain attack escalation (1,184+ malicious skills), new critical CVEs (CVSS 9.8), 42,000 exposed servers, Steinberger joins OpenAI, open-source foundation, broader agentic AI threat landscape
• The Big Three — GPT-5.4 launch, Claude Sonnet 4.6, Gemini 3.1 Pro, Meta Llama 4, DeepSeek V4 controversy. Updated comparison table context windows.
• Clinical Decision Support — RecovryAI FDA Breakthrough, Mount Sinai LLM misinformation study, Doctronic jailbreak
• Ambient AI Tools — athenahealth free scribe, Nabla vs DAX RCT (72K encounters), Dragon Copilot 100K clinicians
• AI-Powered Search — Perplexity Computer (19-model orchestration), Comet browser zero-click security exploits, NotebookLM Gemini 3.1 Pro upgrade
• PHI, HIPAA, and AI — Doctronic SOAP note injection risk, HHS HTI-5 transparency rollback, DeepSeek data concerns, Comet file exfiltration
• Bias, Ethics, and Training Data — Mount Sinai misinformation study, AI chatbots worsening mental illness (Brown University), International AI Safety Report, updated FDA device counts
• When Patients Use AI Too — AI chatbot mental health crisis research, Doctronic and RecovryAI as contrasting patient-facing AI models
• Vibe Coding — GPT-5.4 computer use, Cursor JetBrains integration, Claude Code updates, Gemini Flash-Lite
• So...What Next? — Agentic AI goes mainstream (HIMSS), Llama 4 open-weight for local deployment, AWS Health AI agents, updated browser security warnings
• Start Here — NotebookLM Gemini 3.1 Pro upgrade with 1M context and PPTX export
• AI 101 for Medical Learners — AI chatbot mental health warnings, Doctronic example
• AI's Environmental Footprint — NVIDIA 70% healthcare AI deployment stat
• Glossary — Expanded “Agentic AI” definition

Site-Wide

• Bumped site version from v1.2 · 2026 to v1.3 · 2026 across all pages
• Updated card dates on homepage for all revised modules

v1.2 — February 2026

New Module

• OpenClaw — The viral AI agent that went from Clawdbot to Moltbot to OpenClaw in five weeks—and exposed why autonomous agents put your API keys, credentials, and patient data at risk. Includes curated resources from OX Security, CrowdStrike, Kaspersky, VirusTotal, Lex Fridman #491, and more.

New Content

• AI News — 14 new stories (Feb 3–16) covering the Pentagon vs Anthropic, the February model rush, Dr. Oz's AI avatar plan, GPT-4o retirement, GPT-5.3-Codex-Spark, Claude Opus 4.6, Perplexity Model Council, and more
• Vibe Coding “Something's Changed” — New section covering Claude Opus 4.6 (1M token context, agent teams), GPT-5.3-Codex-Spark (Cerebras chips), and the broader February 2026 model rush

Module Updates

• The Big Three — Updated for GPT-4o retirement, Claude Opus 4.6 with 1M token context and $30B funding round, Gemini reaching 750M MAU. Added February 2026 Update callout.
• So...What Next? — Added OpenClaw cross-reference in AI Agents section
• PHI, HIPAA, and AI — Added OpenAI Lockdown Mode for Healthcare and OpenClaw credential risk callout
• Clinical Decision Support — Added FDA January 2026 AI CDS guidance update
• AI-Powered Search — Added Perplexity Model Council launch callout
• Bias, Ethics, and Training Data — Updated FDA-authorized AI device count from 882 to 950+

Site-Wide

• Bumped site version from v1.1 · 2025 to v1.2 · 2026 across all pages
• Updated card dates on homepage for all revised modules

v1.1 — December 2025

New Modules

• So...What Next? — A comprehensive guide (~6,200 words) for learners who've completed the curriculum. Covers staying current, finding your niche, developer foundations (Git, command line, APIs), AI-powered development tools, AI agents, and practical first projects.
• AI-Powered Search — Answer engines, deep research tools, and knowing when to just Google it. Covers Perplexity, ChatGPT Search, Google AI Overviews, and medical-specific search considerations.

New Content

• 2025 AI landscape overview — Updated coverage of GPT-5/5.1/5.2, Claude Opus 4/4.5, Gemini 3, and DeepSeek releases
• AI Evaluation (Evals) deep dive — Why evaluation methodology matters for clinical AI deployment, core concepts, and learning resources
• AI Agents section — What agents are, healthcare use cases, risks and safety considerations, current technologies (n8n, LangChain, MCP)
• AI Browsers (Comet, Atlas) — Overview of agentic browsers with warnings about prompt injection and why they're not ready for clinical use
• Developer Foundations — Expanded tutorials on Git, command line, and APIs including step-by-step API key setup for OpenAI, Anthropic, and Google
• Tool deep dives — Detailed coverage of Cursor, Claude Code, and Codex with safety warnings about autonomous operation
• Lenny's Pass — Information about the newsletter subscription bundle that provides access to multiple AI tools

New Resources Added

• Simon Willison's Blog — Added to information diet recommendations
• AI Cred — Nate's resource to learn and test AI knowledge
• Your AI Product Needs Evals — Hamel Husain's introduction to evaluation
• Parlance Labs AI Evals Course — Comprehensive evaluation methodology
• GitHub, Codecademy, and freeCodeCamp learning resources for developer foundations
• Command line safety warning with link to cautionary incident

Module Updates

• The Big Three — Significant rewrite to focus on practical/structural differences rather than subjective quality claims. Added "Knowing Your Options" market context, "Just Pick One and Start" guidance, and "Evaluate With Your Own Use Cases" section. Removed claims about model "strengths" that shift with every update.
• AI Image and Video Creation — Updated with OpenAI's GPT Image 1.5 release (December 16, 2025). New model is 4x faster with improved text rendering, precise editing with facial likeness consistency, and new dedicated Images experience in ChatGPT sidebar.
• LLM Thinking — Added BMJ article on "Parallel pressures: the common roots of doctor bullshit and large language model hallucinations"
• Clinical Decision Support — Added "Semantic Drift" section featuring Dr. Olivia Milgrom's analysis of the OpenEvidence/oxacillin dosing incident
• Bias, Ethics, and Training Data — New module added to Foundations section
• When Patients Use AI Too — Enhanced with empathy-focused approach and expanded provider tools section
• Ambient AI Tools — Updated with 2025 research and current scribe landscape
• Everyday Ways to Use AI — Updated with 2025 tools and practical examples
• Vibe Coding — Expanded coverage of AI-powered development tools

Site Improvements

• Module update dates — Each topic card on the home screen now displays when it was last updated, helping you identify recently revised content
• Buy Me a Coffee — Added support button to About page for those who find the guide helpful
• Author bio — Added background information on the About page
• Contribute form — Wired up the contribution form for submitting suggestions and corrections

Fixes & Cleanup

• Fixed multiple broken links across PHI/HIPAA, Start Here, and other modules
• Removed outdated or non-functional resources (Two Minute Papers, Aitrepreneur, some Reddit communities)
• Updated NotebookLM tutorial link to current Google documentation
• Various typo and formatting corrections

v1.0 — November 2025

Initial Release

First public release of AI 101: A Self-Paced Guide to AI in Medicine.

Foundations Modules

• Start Here — Introduction using NotebookLM
• How LLMs Think Like Clinicians — Mental models for understanding AI
• PHI, HIPAA, and AI — Privacy considerations for clinical AI
• The Art of the Ask — Effective prompting techniques
• The Big Three — Guide to ChatGPT, Claude, and Gemini
• AI 101 for Medical Learners — Student and trainee-focused guidance

Using AI Modules

• Clinical Decision Support Tools — From UpToDate to OpenEvidence
• Ambient AI Tools — AI scribes in practice
• AI Image and Video Creation — Visual AI for healthcare
• Everyday Ways to Use AI — AI beyond medicine
• When Patients Use AI Too — Guiding patient AI use
• Vibe Coding — Building software without writing code

Resources

• AI's Environmental Footprint — Sustainability considerations
• Running AI Models Locally — Technical guide for local deployment
• AI Glossary & Learning Resources — Reference and further learning

Staying Updated

Bookmark this page and check back periodically to see what's new. You can also view the full commit history on GitHub.